“Moderna stock surges as melanoma vaccine trial shows ‘landmark moment’”
What actually happened
Merck and Moderna announced topline results from the Phase 3 INTerpath-001 trial, saying the combination of Moderna's personalized mRNA therapy intismeran autogene and Merck's Keytruda met its endpoints, improving recurrence-free and distant metastasis-free survival versus Keytruda alone in patients with surgically removed, high-risk melanoma. This was the first Phase 3 study to demonstrate statistically significant and clinically meaningful improvements in RFS and DMFS compared to KEYTRUDA alone for these patients in the adjuvant melanoma setting. Moderna and Merck said they plan to present the data at an upcoming international medical meeting rather than releasing full figures now.
Key facts
- Shares of Moderna surged $91.52, or 145%, to $154.48 in morning trading after touching an intraday high of $163. Merck's shares rose $14.35, or 10.6%, to $149.52, per CBS's own reporting.
- Other outlets tracking the same trading session logged different snapshots: Forbes reported Moderna rocketed by 125.9% to around $142 on Wednesday, while 24/7 Wall St. cited a roughly 93% gain, and WHBL had shares near $160.25, reflecting normal intraday volatility rather than a factual discrepancy.
- The underlying study was the first Phase 3 study of its kind to show that treatment in combination with pembrolizumab can reduce the risk of recurrence or death in patients with completely resected stage IIB-IV melanoma compared to KEYTRUDA alone, per principal investigator Professor Georgina Long, but no hazard ratio or percentage risk reduction was published alongside that claim.
- The trial covers people who have already had surgery to remove melanoma (adjuvant setting), not a preventive shot for the general population, a distinction the CBS article does explain in its body text.
What to watch for
Watch for the actual effect-size data (hazard ratios, absolute percentage-point improvements) when Merck and Moderna present at the upcoming medical meeting; a modest numeric benefit dressed up as a "landmark" would be the tell. Also watch whether the stock gain holds once full peer-reviewed data replaces the topline press release, since biotech pops on unpublished results often partially reverse.
